talk about和talk of的区别是意思不同、用法不同。talk about的意思是谈论关于什么事情，talk of的意思是谈论某事，一个是关于某人某物某事，一个是直接谈论。

例句：I had a long talk about this with my best friend。我和我最好的朋友就此事进行了长谈。Let's not talk about it.; Don't mention it.别提了。There's been talk of a retaliatory blockade to prevent supplies getting through.有人在谈论实施报复性封锁，阻止供应物资通过。